Side effects noted in studies include (40Trusted Source):
  • Diarrhea
  • Changes in appetite and weight
  • Fatigue
CBD is also known to interact with several medications. Before you start using CBD oil, discuss it with your doctor to ensure your safety and avoid potentially harmful interactions (41Trusted Source). This is especially important if you take medications or supplements that come with a "grapefruit warning." Both grapefruit and CBD interfere with cytochromes P450 (CYPs), a group of enzymes that are important to drug metabolism (42). One study performed on mice showed that CBD-rich cannabis extracts have the potential to cause liver toxicity. However, some of the mice in the study were force-fed extremely large doses of the extract (43). SUMMARYAlthough CBD is generally considered safe, it can cause adverse reactions like diarrhea and fatigue in some people. It may also interfere with certain medications. Is CBD Legal? Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level but are still illegal under some state laws. Marijuana-derived CBD products are illegal on the federal level but are legal under some state laws. Check your state’s laws and those of anywhere you travel. Keep in mind that nonprescription CBD products are not FDA-approved, and maybe inaccurately labeled.
What I would love to know is if any of my readers have tried CBD for pain relief and if so did it help?